benzyl 3-(hydroxyMethyl)pyrrolidine-1-carboxylate

benzyl 3-(hydroxyMethyl)pyrrolidine-1-carboxylate - Names and Identifiers

Name	1-Cbz-3-hydroxymethylpyrrolidine
Synonyms	1-CBZ-DL-BETA-PROLINOL 1-CBZ-3-HYDROXYMETHYLPYRROLIDINE 1-Cbz-3-hydroxymethylpyrrolidine 3-HYDROXYMETHYL-1-CBZ-PYRROLIDINE benzyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate benzyl 3-(hydroxyMethyl)pyrrolidine-1-carboxylate 3-Hydroxymethylpyrrolidine-1-carboxylic acid benzyl ester 1-Pyrrolidinecarboxylic acid, 3-(hydroxymethyl)-, phenylmethyl ester
CAS	315718-05-9
InChI	InChI=1/C13H17NO3/c15-9-12-6-7-14(8-12)13(16)17-10-11-4-2-1-3-5-11/h1-5,12,15H,6-10H2

benzyl 3-(hydroxyMethyl)pyrrolidine-1-carboxylate - Physico-chemical Properties

Molecular Formula	C13H17NO3
Molar Mass	235.28
Density	1.196±0.06 g/cm3(Predicted)
Boling Point	382.0±25.0 °C(Predicted)
Flash Point	184.8°C
Vapor Presure	1.62E-06mmHg at 25°C
pKa	14.93±0.10(Predicted)
Storage Condition	2-8°C
Refractive Index	1.56

benzyl 3-(hydroxyMethyl)pyrrolidine-1-carboxylate - Introduction

It is an organic compound whose chemical structure has a hydroxymethyl group (OH) and a protecting group (Cbz) attached to the third carbon of the pyrrolidine ring.

Properties: It is a solid, its appearance is white or similar to white crystals, and has a special smell. It is stable at room temperature and soluble in some organic solvents such as methanol and dichloromethane.

Uses: It is an important organic synthesis intermediate and is widely used in organic chemical synthesis. It is often used as a starting material for the synthesis of other compounds, such as synthetic drugs, the synthesis of natural products, and synthetic ligands.

preparation method: There are many preparation methods. The common method is to react pyrrolidine with Rhodamine B(Rhodamine B) at a certain concentration, and then add oxidizing sodium nitrite (NaNO2) the oxidation reaction is carried out, and finally the target product is obtained by purification and crystallization.

Safety information: It is stable under normal operating conditions, but care should be taken to avoid contact with skin, eyes and inhalation of gases. Personal protective measures such as gloves and goggles should be taken during use. Specific handling and storage requirements need to be understood and noted in detail in accordance with safety data sheets or relevant chemical information. At the same time, the correct laboratory safety operation specifications should be followed during use.

Last Update：2024-04-09 21:11:58